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C–H fluorination

U can fluorinate unactivated bonds

Introducing C–F bonds into organic molecules is a challenging task, particularly through C–H activation methods. Now, a uranium-based photocatalyst turns traditional selectivity rules on their heads and fluorinates unfunctionalized alkane Csp3–H bonds, even in the presence of C–H bonds that are typically more reactive.

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Figure 1: Preliminary results for selectivity towards traditionally less reactive C–H bonds.


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Correspondence to Tobias Ritter.

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Neumann, C., Ritter, T. U can fluorinate unactivated bonds. Nature Chem 8, 822–823 (2016).

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