Introducing C–F bonds into organic molecules is a challenging task, particularly through C–H activation methods. Now, a uranium-based photocatalyst turns traditional selectivity rules on their heads and fluorinates unfunctionalized alkane Csp3–H bonds, even in the presence of C–H bonds that are typically more reactive.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Liu, W., Huang, M.-J., Nielsen, R. J., Goddard, W. & Groves, J. T. Science 337, 1322–1325 (2012).
West, J. G., Bedell, T. A. & Sorensen, E. J. Angew. Chem. Int. Ed. 55, 8923 (2016).
Bloom, S., Knippel, J. L. & Lectka, T. Chem. Sci. 5, 1175–1178 (2014).
Halperin, S. D., Fan, H., Chang, S., Martin, R. E. & Britton, R. Angew. Chem. Int. Ed. 53, 4690–4693 (2014).
Xia, J.-B., Zhu, C. & Chen, C. Chem. Commun. 50, 11701–11704 (2014).
Kee, C. W., Chin, K. F., Wong, M. W. & Tan, C.-H. Chem. Commun. 50, 8211–8214 (2014).
About this article
Cite this article
Neumann, C., Ritter, T. U can fluorinate unactivated bonds. Nature Chem 8, 822–823 (2016). https://doi.org/10.1038/nchem.2604