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DNA reaction networks

Providing a panoramic view

A quantitative understanding of the functional landscape of a biochemical circuit can reveal the design rules required to optimize the circuit. Now, a high-throughput droplet-based microfluidic platform has been developed which enables high-resolution mapping of bifurcation diagrams for two nonlinear DNA networks.

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Figure 1: High-resolution mapping bifurcation diagrams of nonlinear DNA circuits.

References

  1. Hariadi, R. F. et al. Nature Nanotech. 10, 696–700 (2015).

    Article  CAS  Google Scholar 

  2. Douglas, S. M., Bachelet, I. & Church, G. M. Science 335, 831–834 (2012).

    Article  CAS  Google Scholar 

  3. Adleman, L. M. Science 266, 1021–1024 (1994).

    Article  CAS  Google Scholar 

  4. Benenson, Y. Nature Rev. Genetics 13, 455–468 (2012).

    Article  CAS  Google Scholar 

  5. Qian, L. & Winfree, E. Science 332, 1196–1201 (2011).

    Article  CAS  Google Scholar 

  6. Zhang, D. Y. & Winfree, E. J. Am. Chem. Soc. 131, 17303–17314 (2009).

    Article  CAS  Google Scholar 

  7. Hasatani, K. et al. Chem. Commun. 49, 8090–8092 (2013).

    Article  CAS  Google Scholar 

  8. Genot, A. J. et al. Nature Chem. 8, 760–767 (2016).

    Article  CAS  Google Scholar 

  9. Padirac, A., Fujii, T. & Rondelez, Y. Proc. Natl Acad. Sci. USA 109, 4–6 (2012).

    Article  Google Scholar 

  10. Fujii, T. & Rondelez, Y. ACS Nano 7, 27–34 (2012).

    Article  Google Scholar 

  11. Regot, S. et al. Nature 469, 207–211 (2011).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Chunhai Fan.

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Wang, F., Fan, C. Providing a panoramic view. Nature Chem 8, 738–740 (2016). https://doi.org/10.1038/nchem.2583

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