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Metalloproteins

A switch for blue copper proteins?

Nature Chemistry volume 8, pages 639–641 (2016)Cite this article

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Nitric oxide (NO) has important functions in all forms of life and serves, for example, as a signalling molecule in mammals. Now, two complementary studies have uncovered how NO binds to blue copper proteins. This research suggests a mechanism by which NO could regulate the activity of blue copper proteins involved in denitrification.

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Figure 1: Reaction of NO with blue copper centres.
Figure 2: Reversible formation of an S–nitrosothiol adduct.

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Authors and Affiliations

  1. Subhra Samanta and Nicolai Lehnert are in the Department of Chemistry and Department of Biophysics, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA,

    Subhra Samanta & Nicolai Lehnert

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  1. Subhra Samanta
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  2. Nicolai Lehnert
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Correspondence to Nicolai Lehnert.

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Samanta, S., Lehnert, N. A switch for blue copper proteins?. Nature Chem 8, 639–641 (2016). https://doi.org/10.1038/nchem.2561

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