Membraneless organelles

Phasing in and out

The low-complexity-protein, liquid phases of membraneless organelles have now been established to selectively partition biomolecules. The specialized microenvironment that they provide differs chemically from the surrounding medium and enables specific nucleic-acid remodelling reactions.

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Figure 1: Ddx4N1 liquid droplets selectively partition biomolecules and can alter nucleic acid structure.

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Correspondence to James Shorter.

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Shorter, J. Phasing in and out. Nature Chem 8, 528–530 (2016). https://doi.org/10.1038/nchem.2534

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