Antibacterials

A sweet vaccine

  • A Correction to this article was published on 21 October 2016

Vaccination with a synthetic glycoconjugate, in combination with the administration of an inhibitor that blocks capsular polysaccharide synthesis in bacteria, could offer an alternative route to combat bacterial infections.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Inhibition of capsular polysaccharide (CPS) export enables recognition and killing of bacteria.

Change history

  • 18 October 2016

    In the News & Views 'A sweet vaccine' (Nature Chemistry 8, 201–202; 2016), an in-house error meant that Ben Davis was twice referred to as Ben Davies. This error has been corrected after print 18 October 2016

References

  1. 1

    Liu, Y. et al. Lancet Infect. Dis. 16, 161–168 (2016).

    Article  Google Scholar 

  2. 2

    Kong, L. et al. Nature Chem. 8, 242–249 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Fu, Y., Baumann, M., Kosma, P., Brade, L. & Brade, H. Infect. Immun. 60, 1314–1321 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. 4

    Borrelli, S., Diab, A., Lindberg, A. & Svanborg, C. Microb. Pathogenesis 28, 1–8 (2000).

    CAS  Article  Google Scholar 

  5. 5

    Plested, J. S. et al. J. Infect. Dis. 187, 1223–1234 (2003).

    CAS  Article  Google Scholar 

  6. 6

    Gidney, M. A. et al. Infect. Immun. 72, 559–569 (2004).

    CAS  Article  Google Scholar 

  7. 7

    Müller-Loennies, S., Brade, L. & Brade, H. Int. J. Med. Microbiol. 297, 321–340 (2007).

    Article  Google Scholar 

  8. 8

    Jäkel, A. et al. Vaccine 26, 6655–6663 (2008).

    Article  Google Scholar 

  9. 9

    Parker, M. J. et al. Glycobiology 24, 442–449 (2014).

    CAS  Article  Google Scholar 

  10. 10

    Müller-Loennies, S. et al. J. Endotoxin. Res. 8, 295–305 (2002).

    Article  Google Scholar 

  11. 11

    Boltje, T. J. et al. J. Am. Chem. Soc. 134, 14255–14262 (2012).

    CAS  Article  Google Scholar 

  12. 12

    Yang, Y., Oishi, S., Martin, C. E. & Seeberger, P. H. J. Am. Chem. Soc. 135, 6262–6271 (2013).

    CAS  Article  Google Scholar 

  13. 13

    Reinhardt, A. et al. Chem. Biol. 22, 38–49 (2015).

    CAS  Article  Google Scholar 

  14. 14

    Dong, C. et al. Nature 444, 226–229 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to David Bundle.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bundle, D. A sweet vaccine. Nature Chem 8, 201–202 (2016). https://doi.org/10.1038/nchem.2468

Download citation

Further reading