Biomimetic catalysis

Taking on the turnover challenge

Emulating the efficiency with which enzymes catalyse reactions has often been used as inspiration to develop self-assembled cages. Now two studies present approaches to achieving catalyst turnover — one of the biggest challenges in achieving truly biomimetic catalysis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Controlling catalysis in cages.

References

  1. 1

    Brown, C. J., Toste, F. D., Bergman, R. G. & Raymond, K. N. Chem. Rev. 115, 3012–3035 (2015).

  2. 2

    Kang, J. & Rebek, J. Jr Nature 382, 239–241 (1996).

  3. 3

    Kang, J. & Rebek, J. Jr Nature 385, 50–52 (1997).

  4. 4

    Yoshizawa, M., Tamura, M. & Fujita, M. Science 312, 251–254 (2006).

  5. 5

    Pluth, M. D., Bergman, R. G. & Raymond, K. N. Science 316, 85–88 (2007).

  6. 6

    Sato, S. et al. Science 313, 1273–1276 (2006).

  7. 7

    Hooley, R. J., Biros, S. M. & Rebek, J. Jr Angew. Chem. Int. Ed. 45, 3517–3519 (2006).

  8. 8

    Fiedler, D., Bergman, R. G. & Raymond, K. N. Angew. Chem. Int. Ed. 43, 6748–6755 (2004).

  9. 9

    Kaphan, D. M., Levin, M. D., Bergman, R. G., Raymond, K. N. & Toste, F. D. Science 350, 1235–1238 (2015).

  10. 10

    Cullen, W., Misuraca, M. C., Hunter, C. A., Williams, N. H. & Ward, M. D. Nature Chem. 8, 231–236 (2016).

  11. 11

    Wang, Q.-Q. et al. Nature Chem. 8, 225–230 (2016).

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Richard J. Hooley.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hooley, R. Taking on the turnover challenge. Nature Chem 8, 202–204 (2016). https://doi.org/10.1038/nchem.2461

Download citation

Further reading