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Protein modification

Standing out from the crowd

The discovery of a tetrapeptide containing a reactive cysteine provides a method to site-selectively modify peptides and proteins, even if other cysteine residues are present in the polypeptide chain.

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Figure 1: Construction of the antibody–drug conjugate through site-specific bioconjugation of a single thiol using an engineered antibody.


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Correspondence to Lei Liu.

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Huang, Y., Liu, L. Standing out from the crowd. Nature Chem 8, 101–102 (2016).

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