Molecular machines

Molecules bearing robotic arms

Mass production at the nanoscale requires molecular machines that can control, with high fidelity, the spatial orientation of other reactive species. The demonstration of a synthetic system in which a molecular robotic arm can be used to manipulate the position of a chemical cargo is a significant step towards achieving this goal.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A hydrazone-based molecular switch.
Figure 2: A multistep switching sequence enables a robotic arm to shift a cargo from one aldehyde docking station to another.

References

  1. 1

    Feynman, R. P. Eng. Sci. 23, 22–36 (1960).

    Google Scholar 

  2. 2

    Gu, H., Chao, J., Xiao, S.-J. & Seeman, N. C. Nature 465, 202–205 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Baum, R. Chem. Eng. News 81, 37–42 (2004).

    Google Scholar 

  4. 4

    Kassem, S., Lee, A. T. L., Leigh, D. A., Markevicius, A. & Solà, J. Nature Chem. 8 138–143 (2016).

    CAS  Article  Google Scholar 

  5. 5

    Su, X. & Aprahamian, I. Org. Lett. 13, 30–33 (2011).

    CAS  Article  Google Scholar 

  6. 6

    Astumian, R. D. & Derényi, I. Eur. Biophys. J. 27, 474–489 (1998).

    CAS  Article  Google Scholar 

  7. 7

    Ray, D., Foy, J. T., Hughes, R. P. & Aprahamian, I. Nature Chem. 4, 757–762 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Nitschke, J. R. Nature 462, 736–738 (2009).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ivan Aprahamian.

Additional information

Twitter: @aprahamian

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Aprahamian, I. Molecules bearing robotic arms. Nature Chem 8, 97–99 (2016). https://doi.org/10.1038/nchem.2435

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing