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Chiral cascades

Racemic or enantiomerically pure alcohols can be converted with high yield into enantiopure chiral amines in a one-pot redox-neutral cascade process by the clever combination of an alcohol dehydrogenase and an appropriate amine dehydrogenase.

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Figure 1: Scheme showing the one-pot amination of racemic alcohols to form either (R)- or (S)-amines via a dual-enzyme cascade4.


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Correspondence to Manfred T. Reetz.

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Wang, Jb., Reetz, M. Chiral cascades. Nature Chem 7, 948–949 (2015).

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