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C–H activation

Following directions

Controlling the site-selectivity of C–H activation reactions is a major obstacle for the development of synthetically useful methodology. Now, meta-C–H functionalizations of arenes have been achieved by exploiting weak secondary interactions of a metal-coordinating ligand with the substrate.

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Figure 1: Strategies for meta-selective C–H functionalization.


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Correspondence to Lutz Ackermann.

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Ackermann, L., Li, J. Following directions. Nature Chem 7, 686–687 (2015).

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