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Synthetic biology

Six pack and stack

Nature Chemistry volume 7, pages 617–619 (2015)Cite this article

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A pair of artificial DNA bases have now been shown to adopt an edge-to-edge geometry in DNA which is similar that found in Watson–Crick base pairing. Aptamers containing these bases have also been shown to bind more strongly to a target than those developed using only the four naturally occurring bases.

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Figure 1: Comparison of the structures of the expanded genetic alphabets.

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Authors and Affiliations

  1. Cheulhee Jung and Andrew D. Ellington are in the Institute for Cellular and Molecular Biology, University of Texas at Austin, University Station A4800, Austin, Texas 78712-0165, USA,

    Cheulhee Jung & Andrew D. Ellington

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  1. Cheulhee Jung
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  2. Andrew D. Ellington
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Correspondence to Andrew D. Ellington.

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Jung, C., Ellington, A. Six pack and stack. Nature Chem 7, 617–619 (2015). https://doi.org/10.1038/nchem.2313

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