How complex is it to synthesize a given molecular target? Can this be answered by a computer? Now, a model of synthetic complexity that factors in methodology developments has resulted in a complexity index that evolves alongside them.
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Gasteiger, J. Computing target complexity. Nature Chem 7, 619–620 (2015). https://doi.org/10.1038/nchem.2311
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DOI: https://doi.org/10.1038/nchem.2311
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