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Bioorthogonal catalysis

Rise of the nanobots

Bioorthogonal catalysis provides new ways of mediating artificial transformations in living environs. Now, researchers have developed a nanodevice whose catalytic activity can be regulated by host–guest chemistry.

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Figure 1: Spatiotemporal resolution of the sequential actions performed by Rotello's nanobots.


  1. Douglas, S. M., Bachelet, I. & Church, G. M. Science 335, 831–834 (2012).

    Article  CAS  Google Scholar 

  2. Amir, Y. et al. Nature Nanotech. 9, 353–357 (2014).

    Article  CAS  Google Scholar 

  3. Drexler, K. E. Nanosystems, Molecular Machinery, Manufacturing and Computation (Wiley, 1992).

    Google Scholar 

  4. Renggli, K. et al. Adv. Funct. Mater. 21, 1241–1259 (2011).

    Article  CAS  Google Scholar 

  5. Streu, C. & Meggers, E. Angew. Chem. Int. Ed. 45, 5645–5648 (2006).

    Article  CAS  Google Scholar 

  6. Yusop, R. M., Unciti-Broceta, A., Johansson, E. M. V., Sánchez-Martín, R. M. & Bradley, M. Nature Chem. 3, 239–243 (2011).

    Article  CAS  Google Scholar 

  7. Weiss, J. T. et al. Nature Commun. 5, 3277 (2014).

    Article  Google Scholar 

  8. Sletten, E. M. & Bertozzi, C. R. Angew. Chem. Int. Ed. 48, 6974–6998 (2009).

    Article  CAS  Google Scholar 

  9. Tonga, G. Y. et al. Nature Chem. 7, 597–603 (2015).

    Article  CAS  Google Scholar 

  10. Kim, C., Agasti, S. S., Zhu, Z., Isaacs, L. & Rotello, V. M. Nature Chem. 2, 962–966 (2010).

    Article  CAS  Google Scholar 

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Correspondence to Asier Unciti-Broceta.

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Unciti-Broceta, A. Rise of the nanobots. Nature Chem 7, 538–539 (2015).

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