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Analytical chemistry

Clamping down on cancer detection

Nature Chemistry volume 7, pages 541–542 (2015)Cite this article

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An electrochemical clamp assay that enables the rapid and sensitive detection of nucleic acids containing single base mutations has now been developed. It has been shown to differentiate between cancer patient samples featuring a specific mutation, and controls from healthy donors or other cancer patients, all directly in unprocessed serum.

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Figure 1: The design of the electrochemical clamp assay enables the rapid, specific and sensitive detection of nucleic acids containing a single base mutation.

References

  1. Kelley, S. O. et al. Nature Nanotech. 9, 969–980 (2014).

    Article  CAS  Google Scholar 

  2. Grieshaber, D., MacKenzie, R., Vörös, J. & Reimhult, E. Sensors 8, 1400–1458 (2008).

    Article  CAS  Google Scholar 

  3. Sadik, O. A., Aluoch, A. O. & Zhou, A. Biosens. Bioelectron. 24, 2749–2765 (2009).

    Article  CAS  Google Scholar 

  4. Aung, K. L. et al. HUGO J. 4, 11–21 (2010).

    Article  CAS  Google Scholar 

  5. Bettegowda, C. et al. Sci. Transl. Med. 6, 224ra24 (2014).

    Article  Google Scholar 

  6. Murtaza, M. et al. Nature 497, 108–112 (2013).

    Article  CAS  Google Scholar 

  7. Das, J. et al. Nature Chem. 7, 569–575 (2015).

    Article  CAS  Google Scholar 

  8. Chiou, C-C., Luo, J-D. & Chen, T-L. Nature Protoc. 1, 2604–2612 (2006).

    Article  CAS  Google Scholar 

  9. National Cancer Institute Pancreatic Cancer www.cancer.gov/cancertopics/types/pancreatic (accessed 18 May 2015).

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Authors and Affiliations

  1. Alon A. Gorodetsky is in the Department of Chemical Engineering and Materials Science, University of California, Irvine, Irvine, California 92697, USA,

    Alon A. Gorodetsky

  2. Irina A. Gorodetskaya is a scientific advisor for the Gorodetsky Group,

    Irina A. Gorodetskaya

Authors
  1. Irina A. Gorodetskaya
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  2. Alon A. Gorodetsky
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Correspondence to Alon A. Gorodetsky.

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Gorodetskaya, I., Gorodetsky, A. Clamping down on cancer detection. Nature Chem 7, 541–542 (2015). https://doi.org/10.1038/nchem.2290

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