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Analytical chemistry

Clamping down on cancer detection

An electrochemical clamp assay that enables the rapid and sensitive detection of nucleic acids containing single base mutations has now been developed. It has been shown to differentiate between cancer patient samples featuring a specific mutation, and controls from healthy donors or other cancer patients, all directly in unprocessed serum.

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Figure 1: The design of the electrochemical clamp assay enables the rapid, specific and sensitive detection of nucleic acids containing a single base mutation.

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Correspondence to Alon A. Gorodetsky.

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Gorodetskaya, I., Gorodetsky, A. Clamping down on cancer detection. Nature Chem 7, 541–542 (2015). https://doi.org/10.1038/nchem.2290

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