Replication of long nucleic acid sequences was required for the evolution of biological complexity during the origin of life; however, short sequences are normally better replicators than long ones. A common physical environment now provides a simple mechanism to reverse this trend and enables long sequences to flourish.
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Kreysing, M., Keil, L., Lanzmich, S. & Braun, D. Nature Chem. 7, 203–208 (2015).
Mills, D. R., Peterson, R. L. & Spiegelman, S. Proc. Natl Acad. Sci. USA 58, 217–224 (1967).
Ichihashi, N., Usui, K., Kazuta, Y., Sunami, T., Matsuura, T. & Yomo, T. Nature Commun. 4, 2494 (2013).
Reichl, M., Herzog, M., Gotz, A. & Braun, D. Phys. Rev. Lett. 112, 198101 (2014).
Eigen, M. Naturwissenschaften 58, 465–523 (1971).
Rajamani, S. et al. J. Am. Chem. Soc. 132, 5880–5885 (2010).
Zhang, S., Blain, J. C., Zielinska, D., Gryaznov, S. M. & Szostak, J. W. Proc. Natl Acad. Sci. USA 110, 17732–17737 (2013).
Attwater, J., Wochner, A. & Holliger, P. Nature Chem. 5, 1011–1018 (2013).
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Chen, I. Replicating towards complexity. Nature Chem 7, 191–192 (2015). https://doi.org/10.1038/nchem.2188
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