Mutated enzymes are useful tools for the investigation of the biosynthetic routes to natural products. Now, they are used in a new approach to carry functionalized substrates through the synthesis and produce simplified or modified unnatural compounds with useful properties.
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Pryk, N., Schulz, F. Biosynthetic interceptors. Nature Chem 7, 102–104 (2015). https://doi.org/10.1038/nchem.2168
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DOI: https://doi.org/10.1038/nchem.2168
