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Molecular self-assembly

Searching sequence space

Nature Chemistry volume 7, pages 14–15 (2015)Cite this article

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Short peptides are among the most intriguing building blocks in nanotechnology, but it would be very challenging to experimentally study the properties of large numbers of different sequences. Now, a computational analysis of all 8,000 possible tripeptides has been used to identify those with interesting self-assembly behaviour.

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Figure 1: Identification of aggregation-prone tripeptide motifs.

References

  1. Yan, X., Zhu, P. & Li, J. Chem. Soc. Rev. 39, 1877–1890 (2010).

    Article  CAS  Google Scholar 

  2. Hauser, C. A. & Zhang, S. Nature 468, 516–517 (2010).

    Article  CAS  Google Scholar 

  3. Adler-Abramovich, L. & Gazit, E. Chem. Soc. Rev. 43, 6881–6893 (2014).

    Article  CAS  Google Scholar 

  4. Frederix, P. W. J. M. et al. Nature Chem. 7, 30–37 (2015).

    Article  CAS  Google Scholar 

  5. Pawar, A. P. et al. J. Mol. Biol. 350, 379–392 (2005).

    Article  CAS  Google Scholar 

  6. Reches, M. & Gazit, E. Science 300, 625–627 (2003).

    Article  CAS  Google Scholar 

  7. Lütticke, C. et al. Mol. Biosyst. 8, 1775–1782 (2012).

    Article  Google Scholar 

  8. Aida, T., Meijer, E. W. & Stupp, S. I. Science 335, 813–817 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Ehud Gazit is in the Department of Molecular Microbiology and Biotechnology and the Department of Materials Science and Engineering at Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel,

    Ehud Gazit

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  1. Ehud Gazit
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Correspondence to Ehud Gazit.

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Gazit, E. Searching sequence space. Nature Chem 7, 14–15 (2015). https://doi.org/10.1038/nchem.2140

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