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Drug discovery

Combichem all over again

The generation of chemical libraries for screening is a key part of the drug discovery process. Now, two studies describe attempts to combine features of natural product biosynthesis into the creation of libraries with the aim of mimicking nature's success at the production of bioactive molecules.

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Figure 1: Contemporary approaches to combinatorial chemistry.


  1. Mullin, R. Chem. Eng. News 82, 23–32 (2004).

    Google Scholar 

  2. Smith, G. P. & Petrenko, V. A. Chem. Rev. 97, 391–410 (1997).

    Article  CAS  Google Scholar 

  3. Takahashi, T. T., Austin, R. J. & Roberts, R. W. Trends Biochem. Sci. 28, 159–165 (2003).

    Article  CAS  Google Scholar 

  4. Josephson, K., Ricardo, A. & Szostak, J. W. Drug. Discov. Today 19, 388–399 (2014).

    Article  CAS  Google Scholar 

  5. Franzani, R. M., Neri, D. & Scheuermann, J. Acc. Chem. Res. 47, 1247–1255 (2014).

    Article  Google Scholar 

  6. Clark, M. A. et al. Nature Chem. Biol. 5, 647–654 (2009).

    Article  CAS  Google Scholar 

  7. Huang, Y.-L. & Bode, J. W. Nature Chem. 6, 877–884 10.1038/nchem.2048(2014).

    Article  CAS  Google Scholar 

  8. Carrillo, N., Davalos, E. A., Russak, J. A. & Bode, J. W. J. Am Chem. Soc. 128, 1452–1453 (2006).

    Article  CAS  Google Scholar 

  9. Karageorgis, G., Warriner, S. & Nelson, A. Nature Chem. 6, 872–876 10.1038/nchem.2034(2014).

    Article  CAS  Google Scholar 

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Correspondence to Derek B. Lowe.

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Lowe, D. Combichem all over again. Nature Chem 6, 851–852 (2014).

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