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Ion transport

Tipping a cell's ionic balance

A synthetic compound that transports chloride across membranes can kill both normal cells and cancer cells in vitro. The transporter works together with sodium channels to move NaCl into the cells, which triggers cell death.

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Figure 1: Strapped calixpyrroles can bind Cl and transport it across the nonpolar cell membrane.


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Correspondence to Jeffery T. Davis.

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Davis, J. Tipping a cell's ionic balance. Nature Chem 6, 852–853 (2014).

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