For decades chemists have focused on increasing the brightness of fluorophores. In super-resolution microscopy, however, fluorophores that preferentially exist in a non-fluorescent state, but occasionally re-arrange into a fluorescent form, can give better results.
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Lukinavičius, G., Johnsson, K. Strategic blinking. Nature Chem 6, 663–664 (2014). https://doi.org/10.1038/nchem.2020