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Asymmetric synthesis

Cascades of catalytic selectivity

A combination of catalytic asymmetric diboration of terminal alkenes and Suzuki–Miyaura cross-coupling has been exploited in the synthesis of a variety of important medicinal agents. The process overcomes a number of problems in the application of these important catalytic processes.

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Figure 1: Problems and solutions in the asymmetric functionalization of terminal olefins.

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Correspondence to Todd B. Marder.

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Dewhurst, R., Marder, T. Cascades of catalytic selectivity. Nature Chem 6, 279–280 (2014). https://doi.org/10.1038/nchem.1905

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