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Enzymatic C–H bond activation

Using push to get pull

Nature Chemistry volume 6, pages 89–91 (2014)Cite this article

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Cytochrome P450 enzymes are able to oxidize substrates that are more inert than their own surrounding protein framework. Now, a quantitative understanding has emerged as to how the enzymes accomplish this remarkable feat.

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Figure 1: Oxidation of C–H bonds by P450 enzymes, emphasizing the role of the thiolate ligand.

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Authors and Affiliations

  1. John T. Groves is in the Department of Chemistry at Princeton University, Princeton, New Jersey 08544, USA,

    John T. Groves

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  1. John T. Groves
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Correspondence to John T. Groves.

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Groves, J. Using push to get pull. Nature Chem 6, 89–91 (2014). https://doi.org/10.1038/nchem.1855

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