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Natural product biosynthesis

It's all downhill from here

Nature Chemistry volume 6, pages 8889 (2014) | Download Citation

High selectivity is essential in the enzymatic biosynthesis of complex natural products. Now, the discovery of multiple sequential bifurcations on the reaction path towards the formation of a diterpenoid shows how dynamics affect selectivity, and suggests how enzymes may steer reactions towards a specific product.

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Affiliations

  1. Robert S. Paton and Charles E. Hornsby are in the Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK

    • Charles E. Hornsby
    •  & Robert S. Paton

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Correspondence to Robert S. Paton.

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DOI

https://doi.org/10.1038/nchem.1852

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