High selectivity is essential in the enzymatic biosynthesis of complex natural products. Now, the discovery of multiple sequential bifurcations on the reaction path towards the formation of a diterpenoid shows how dynamics affect selectivity, and suggests how enzymes may steer reactions towards a specific product.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Periodic forces trigger knot untying during translocation of knotted proteins
Scientific Reports Open Access 21 March 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ess, D. H. et al. Angew. Chem. Int. Ed. 47, 7592–7601 (2008).
Rehbein, J. & Carpenter, B. K. Phys. Chem. Chem. Phys. 13, 20906–20922 (2011).
Thomas, J. B., Waas, J. R., Harmata, M. & Singleton, D. A. J. Am. Chem. Soc. 130, 14544–14555 (2008).
Hong, Y. J. & Tantillo, D. J. Nature Chem. 6, 104–111 10.1038/nchem.1843(2014).
Paranjothy, M., Sun, R., Zhuang, Y. & Hase, W. L. WIREs Comput. Mol. Sci. 3, 296–316 (2013).
Hong, Y. J. & Tantillo, D. J. Nature Chem. 1, 384–389 (2009).
Sheppard, A. & Acevedo, O. J. Am. Chem. Soc. 131, 2530–2540 (2009).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hornsby, C., Paton, R. It's all downhill from here. Nature Chem 6, 88–89 (2014). https://doi.org/10.1038/nchem.1852
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.1852
This article is cited by
-
Periodic forces trigger knot untying during translocation of knotted proteins
Scientific Reports (2016)
