Biophysical chemistry

Strength in numbers

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Replication of the HIV-1 viral genome can be inhibited by a protein known as APOBEC3G, via two seemingly contradictory mechanisms. Now, the molecular conundrum behind these two processes has been resolved.

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Figure 1: Schematic of the proposed model for the binding of A3G to single-stranded DNA in vitro3.


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Correspondence to Graeme A. King or Gijs J. L. Wuite.

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King, G., Wuite, G. Strength in numbers. Nature Chem 6, 13–14 (2014) doi:10.1038/nchem.1831

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