Biosynthesis

Non-stick natural products

Article metrics

Fluorine imparts many drugs with beneficial properties, however, the synthesis of fluorinated complex natural products is challenging. Biosynthetic strategies and recent experimental precedents have paved the way for bioengineered fluorinated polyketides.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The engineered biosynthesis of simple fluorinated polyketides is achieved with the introduction of fluoromalonyl-CoA as a substrate.

References

  1. 1

    Müller, K., Faeh, C. & Diederich, F. Science 317, 1881–1886 (2007).

  2. 2

    Hagmann, W. K. J. Med. Chem. 51, 4359–4369 (2008).

  3. 3

    O'Hagan, D. Chem. Soc. Rev. 37, 308–319 (2008).

  4. 4

    Furuya, T., Kamlet, A. S. & Ritter, T. Nature 473, 470–477 (2011).

  5. 5

    Dong, C. et al. Nature 427, 561–565 (2004).

  6. 6

    Walker, M. C. et al. Science 341, 1089–1094 (2013).

Download references

Author information

Correspondence to Bradley S. Moore.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Jordan, P., Moore, B. Non-stick natural products. Nature Chem 6, 10–12 (2014) doi:10.1038/nchem.1828

Download citation

Further reading