Non-stick natural products

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Fluorine imparts many drugs with beneficial properties, however, the synthesis of fluorinated complex natural products is challenging. Biosynthetic strategies and recent experimental precedents have paved the way for bioengineered fluorinated polyketides.

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Figure 1: The engineered biosynthesis of simple fluorinated polyketides is achieved with the introduction of fluoromalonyl-CoA as a substrate.


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Correspondence to Bradley S. Moore.

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Jordan, P., Moore, B. Non-stick natural products. Nature Chem 6, 10–12 (2014) doi:10.1038/nchem.1828

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