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Biosynthesis

Non-stick natural products

Nature Chemistry volume 6, pages 10–12 (2014)Cite this article

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Fluorine imparts many drugs with beneficial properties, however, the synthesis of fluorinated complex natural products is challenging. Biosynthetic strategies and recent experimental precedents have paved the way for bioengineered fluorinated polyketides.

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Figure 1: The engineered biosynthesis of simple fluorinated polyketides is achieved with the introduction of fluoromalonyl-CoA as a substrate.

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Authors and Affiliations

  1. Peter A. Jordan and Bradley S. Moore are in the Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA,

    Peter A. Jordan & Bradley S. Moore

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  1. Peter A. Jordan
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  2. Bradley S. Moore
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Correspondence to Bradley S. Moore.

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Jordan, P., Moore, B. Non-stick natural products. Nature Chem 6, 10–12 (2014). https://doi.org/10.1038/nchem.1828

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