Preparing powerful reactive intermediates such as enolates and homoenolates for C–C bond formation used to require strong bases and stoichiometric reagents. They can now be catalytically generated from α-functionalized aldehydes or even from saturated esters under mild conditions using N-heterocyclic carbene catalysts.
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Bode, J. An internal affair. Nature Chem 5, 813–815 (2013). https://doi.org/10.1038/nchem.1766
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DOI: https://doi.org/10.1038/nchem.1766
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