Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Antibiotics

Blocking bacterial defences

Electrochemical sensing of the function of cell-membrane proteins has led to the identification of inhibitors that could provide a new approach to the identification of antimicrobial drugs.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Blocking the bacterial nanopore Wza.

References

  1. Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Nature Rev. Drug Discov. 6, 29–40 (2007).

    Article  CAS  Google Scholar 

  2. Roemer, T. & Boone, C. Nature Chem. Biol. 9, 222–231 (2013).

    Article  CAS  Google Scholar 

  3. Jankute, M., Grover, S., Rana, A. K. & Besra, G. S. Fut. Microbiol. 7, 129–147 (2012).

    Article  CAS  Google Scholar 

  4. Whitfield, C. Ann. Rev. Biochem. 75, 39–68 (2006).

    Article  CAS  Google Scholar 

  5. Neher, E. & Sakmann, B. Nature 260, 799–802 (1976).

    Article  CAS  Google Scholar 

  6. Branton, D. et al. Nature Biotechnol. 26, 1146–1153 (2008).

    Article  CAS  Google Scholar 

  7. Kong, L. et al. Nature Chem. 5, 651–659 10.1038/nchem.1695(2013).

    Article  CAS  Google Scholar 

  8. Dong, C. et al. Nature 444, 226–229 (2006).

    Article  CAS  Google Scholar 

  9. Banerjee, A. et al. Proc. Natl Acad. Sci. USA 107, 8165–8170 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert A. Field.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

O'Neill, E., Field, R. Blocking bacterial defences. Nature Chem 5, 642–643 (2013). https://doi.org/10.1038/nchem.1718

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.1718

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing