Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Blocking bacterial defences

Electrochemical sensing of the function of cell-membrane proteins has led to the identification of inhibitors that could provide a new approach to the identification of antimicrobial drugs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Blocking the bacterial nanopore Wza.


  1. Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Nature Rev. Drug Discov. 6, 29–40 (2007).

    Article  CAS  Google Scholar 

  2. Roemer, T. & Boone, C. Nature Chem. Biol. 9, 222–231 (2013).

    Article  CAS  Google Scholar 

  3. Jankute, M., Grover, S., Rana, A. K. & Besra, G. S. Fut. Microbiol. 7, 129–147 (2012).

    Article  CAS  Google Scholar 

  4. Whitfield, C. Ann. Rev. Biochem. 75, 39–68 (2006).

    Article  CAS  Google Scholar 

  5. Neher, E. & Sakmann, B. Nature 260, 799–802 (1976).

    Article  CAS  Google Scholar 

  6. Branton, D. et al. Nature Biotechnol. 26, 1146–1153 (2008).

    Article  CAS  Google Scholar 

  7. Kong, L. et al. Nature Chem. 5, 651–659 10.1038/nchem.1695(2013).

    Article  CAS  Google Scholar 

  8. Dong, C. et al. Nature 444, 226–229 (2006).

    Article  CAS  Google Scholar 

  9. Banerjee, A. et al. Proc. Natl Acad. Sci. USA 107, 8165–8170 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Robert A. Field.

Rights and permissions

Reprints and permissions

About this article

Cite this article

O'Neill, E., Field, R. Blocking bacterial defences. Nature Chem 5, 642–643 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research