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Enzyme cofactors

Double-edged sword for catalysis

The metal cofactors responsible for the activity of CDK2 — a representative member of the kinase superfamily of enzymes — have now been shown to also have inhibitory effects during the catalytic cycle.

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Figure 1: Revised mechanism for CDK2 illustrates how the same Mg2+ ion can have both activating and inhibitory effects during different steps of the catalytic cycle.

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Correspondence to Ivaylo Ivanov.

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Ivanov, I. Double-edged sword for catalysis. Nature Chem 5, 6–7 (2013). https://doi.org/10.1038/nchem.1529

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