Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Enzyme cofactors

Double-edged sword for catalysis

The metal cofactors responsible for the activity of CDK2 — a representative member of the kinase superfamily of enzymes — have now been shown to also have inhibitory effects during the catalytic cycle.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Revised mechanism for CDK2 illustrates how the same Mg2+ ion can have both activating and inhibitory effects during different steps of the catalytic cycle.


  1. Ivanov, I., Tainer, J. A. & McCammon, J. A. Proc. Natl Acad. Sci. USA 104, 1465–1470 (2007).

    Article  CAS  Google Scholar 

  2. Adams, J. A. Chem. Rev. 101, 2271–2290 (2001).

    Article  CAS  Google Scholar 

  3. Jacobsen, D. M., Bao, Z. Q., O'Brien, P., Brooks, C. L. III & Young, M. A. J. Am. Chem. Soc. 134, 15357–15370 (2012).

    Article  CAS  Google Scholar 

  4. Ubersax, J. A. & Ferrell, J. E. Jr Nature Rev. Mol. Cell Bio. 8, 530–541 (2007).

    Article  CAS  Google Scholar 

  5. Malumbres, M. & Barbacid, M. Nature Rev. Cancer 9, 153–166 (2009).

    Article  CAS  Google Scholar 

  6. Jeffrey, P. D. et al. Nature 376, 313–320 (1995).

    Article  CAS  Google Scholar 

  7. Bao, Z. Q., Jacobsen, D. M. & Young, M. A. Structure 19, 675–690 (2011).

    Article  CAS  Google Scholar 

  8. Khavrutskii, I. V., Grant, B., Taylor, S. S. & McCammon, J. A. Biochemistry 48, 11532–11545 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ivaylo Ivanov.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ivanov, I. Double-edged sword for catalysis. Nature Chem 5, 6–7 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing