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Asymmetric catalysis

The power of pairing

Nature Chemistry volume 4, pages 438–439 (2012)Cite this article

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Supramolecular catalysts that combine an anionic chiral scaffold, a cationic coordinating structure and a metal centre have been shown to be highly effective for asymmetric synthesis. The success opens a new avenue for the design of new catalysts with a wide variety of chiral environments.

Although enormous research efforts have been invested in the synthesis of such compounds, the development of new chiral ligands remains a challenge. Multiple synthetic steps are often required, and phosphines in particular can be problematic as they can be easily oxidized.

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Figure 1: Chiral ligand construction by ion pairing.

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  1. Hajime Ito is in the Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan,

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  1. Hajime Ito
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Ito, H. The power of pairing. Nature Chem 4, 438–439 (2012). https://doi.org/10.1038/nchem.1363

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