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Enzyme mimics

Halogen and chalcogen team up

The behaviour of di-selenol enzyme mimics indicates that a halogen bond between selenium and iodine, and a chalcogen interaction between the two selenium atoms, play an important role in the activation of thyroid hormones.

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Figure 1: The peri-substituted naphthalene-diselenol 1 efficiently removes iodine (shown in purple) from the inner ring of thyroxine (3,5,3′,5′-tetraiodothyronine, T4), yielding 3,3′,5′-triiodothyronine (rT3) (top).


  1. Kuiper, G. G. J. M. et al. J. Endocrinol. 144, 2505–2513 (2003).

    Article  CAS  Google Scholar 

  2. Metrangolo, P. & Resnati, G. Science 321, 918–019 (2008).

    Article  CAS  Google Scholar 

  3. Bayse, C. A. & Rafferty, E. R. Inorg. Chem. 49, 5365–5367 (2010).

    Article  CAS  Google Scholar 

  4. Metrangolo, P. et al. Angew. Chem. Int. Ed. 47, 6114–6127 (2008).

    Article  CAS  Google Scholar 

  5. Goto, K. et al. Angew. Chem. Int. Ed. 49, 545–547 (2010).

    Article  CAS  Google Scholar 

  6. Manna, D. & Mugesh, G. J. Am. Chem. Soc. 134, 4269–4279 (2012).

    Article  CAS  Google Scholar 

  7. Jentzsch, A. V. et al. Angew. Chem. Int. Ed. 50, 11675–11678 (2011).

    Article  Google Scholar 

  8. Kitamura, S. et al. J. Health Sci. 54, 607–614 (2008).

    Article  CAS  Google Scholar 

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Correspondence to Pierangelo Metrangolo or Giuseppe Resnati.

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Metrangolo, P., Resnati, G. Halogen and chalcogen team up. Nature Chem 4, 437–438 (2012).

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