Recent syntheses of the natural product 3-hydroxy-N-methylwelwitindolinone C isothiocyanate are taken as examples to answer an oft-raised question about the value of total synthesis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Quasdorf, K. W., Huters, A. D., Lodewyk, M. W., Tantillow, D. J. & Garg, N. K. J. Am. Chem. Soc. 134, 1396–1399 (2012).
Allan, K. M., Kobayashi, K. & Rawal, V. H. J. Am. Chem. Soc. 134, 1392–1395 (2012).
Stratmann, K. et al. J. Am. Chem. Soc. 116, 9935–9942 (1994).
Jimenez, J. L., Huber, U., Moore, R. E. & Patterson, G. M. L. J. Nat. Prod. 62, 569–572 (1999).
Huters, A. D., Quasdorf, K. W., Styduhar, E. D. & Garg, N. K. J. Am. Chem. Soc. 133, 15797–15799 (2011).
Bhat, V., Allan, K. M. & Rawal, V. H. J. Am. Chem. Soc. 133, 5798–5801 (2011).
Espino C. G. & Du Bois, J. Angew. Chem. Int. Ed. 40, 598–600 (2001).
Richter, J. M. et al. J. Am. Chem. Soc. 130, 17938–17945 (2008).
Kim, S. & Yi, K. Y. J. Org. Chem. 51, 2613–2615 (1986).
Mori, H., Wada, S. & Tsuneda, K. Chem. Pharm. Bull. 11, 684 (1963).
Kim, J. N. & Ryu, E. K. Tetrahedron Lett. 34, 8283 (1993).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wood, J. Welwitindolinone is well worth it. Nature Chem 4, 341–343 (2012). https://doi.org/10.1038/nchem.1335
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.1335
