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Biomimetic chemistry

Merging the old with the new

The classic organometallic compound ferrocene has been combined with a unique diiron unit in the latest synthetic analogue of an enzyme active site, achieving the three functionalities needed for a working model of diiron hydrogenase, itself of ancient origin.

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Figure 1: Model design and connections to the natural biocatalyst.

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Correspondence to Marcetta Y. Darensbourg or Ryan D. Bethel.

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Darensbourg, M., Bethel, R. Merging the old with the new. Nature Chem 4, 11–13 (2012). https://doi.org/10.1038/nchem.1228

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