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RNA structure

Adding a second dimension

Nature Chemistry volume 3, pages 913915 (2011) | Download Citation

Mutating RNA one nucleotide at a time and measuring the impact of this on its chemical reactivity provides a strategy for determining its three-dimensional structure, and from there, hopefully, its function.

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Author information

Affiliations

  1. Katja Petzold and Hashim M. Al-Hashimi are in the Department of Chemistry and Biophysics at the University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA

    • Katja Petzold
    •  & Hashim M. Al-Hashimi

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Competing interests

H.M.A.-H. is an advisor to and holds an ownership interest in Nymirum, an RNA-based drug-discovery company.

Corresponding author

Correspondence to Hashim M. Al-Hashimi.

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DOI

https://doi.org/10.1038/nchem.1209

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