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RNA structure

Adding a second dimension

Mutating RNA one nucleotide at a time and measuring the impact of this on its chemical reactivity provides a strategy for determining its three-dimensional structure, and from there, hopefully, its function.

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Figure 1: From chemical mapping to 3D structure.


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Correspondence to Hashim M. Al-Hashimi.

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Competing interests

H.M.A.-H. is an advisor to and holds an ownership interest in Nymirum, an RNA-based drug-discovery company.

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Petzold, K., Al-Hashimi, H. Adding a second dimension. Nature Chem 3, 913–915 (2011).

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