Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DNA complexes

Durable binders

A tetra-intercalator compound that threads through a DNA double-helix to form a remarkably stable complex exhibits an unusual combination of sequence specificity and rapid association yet slow dissociation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic representation of DNA–ligand complexes.

References

  1. Dervan, P. B. Bioorg. Med. Chem. 9, 2215–2235 (2001).

    Article  CAS  Google Scholar 

  2. Uil, T. G., Haisma, H. J. & Rots, M. G. Nucl. Acids Res. 31, 6064–6078 (2003).

    Article  CAS  Google Scholar 

  3. Nielsen, P. E. Acc. Chem. Res. 32, 624–630 (1999).

    Article  CAS  Google Scholar 

  4. Holman, G. G., Zewail-Foote, M., Johnson, K. A. & Iverson, B. L. Nature Chem. 3, 875–881 (2011).

    Article  CAS  Google Scholar 

  5. Lokey, R. S. et al. J. Am. Chem. Soc. 119, 7202–7210 (1997).

    Article  CAS  Google Scholar 

  6. Lee, J. et al. J. Am. Chem. Soc. 126, 14036–14042 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Adam R. Urbach.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Urbach, A. Durable binders. Nature Chem 3, 836–837 (2011). https://doi.org/10.1038/nchem.1173

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.1173

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing