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Protein NMR spectroscopy

Spinning into focus

Transient sedimentation of proteins inside a solid-state NMR rotor under fast magic-angle spinning offers a promising solution to the challenge of determining the structures of high-molecular-weight proteins with atomic resolution. This opens new opportunities for structural analysis of large macromolecules and macromolecular assemblies.

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Figure 1: A schematic representation of a transient sedimentation NMR experiment.

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Correspondence to Tatyana Polenova.

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Polenova, T. Spinning into focus. Nature Chem 3, 759–760 (2011). https://doi.org/10.1038/nchem.1143

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