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Getting physical to fix pharma

Nature Chemistry volume 3, pages 692–695 (2011)Cite this article

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Powerful technologies allow the synthesis and testing of large numbers of new compounds, but the failure rate of pharmaceutical R&D remains very high. Greater understanding of the fundamental physical chemical behaviour of molecules could be the key to greatly enhancing the success rate of drug discovery.

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Author information

Authors and Affiliations

  1. Mark Murcko is Chief Technology Officer at Vertex Pharmaceuticals, Cambridge, Massachusetts 02139, USA ,

    Mark A. Murcko

  2. Pat Connelly is Senior Director at Materials Discovery & Characterization, also at Vertex Pharmaceuticals, Cambridge, Massachusetts 02139, USA ,

    Patrick R. Connelly

  3. Minh Vuong is Senior Director, Instrumentation Research & Development, at Vertex Pharmaceuticals in San Diego, California, 92121, USA ,

    T. Minh Vuong

Authors
  1. Patrick R. Connelly
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  2. T. Minh Vuong
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  3. Mark A. Murcko
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Corresponding author

Correspondence to Mark A. Murcko.

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Connelly, P., Vuong, T. & Murcko, M. Getting physical to fix pharma. Nature Chem 3, 692–695 (2011). https://doi.org/10.1038/nchem.1121

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