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Bioactive natural products

Function first

The synthesis and biological investigation of a family of natural products and unnatural analogues illustrates the importance of considering both form and function in the planning of any synthesis.

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Figure 1: Synthesis and investigation of the properties of daphnane congeners.

References

  1. Baran, P. S. & Maimone, T. J. Nature Chem. Biol. 3, 396–407 (2007).

    Article  Google Scholar 

  2. Holton, R. A. et al. J. Am. Chem. Soc. 116, 1599–1600 (1994).

    Article  CAS  Google Scholar 

  3. Nicolaou, K. C. et al. Nature 367, 630–634 (1994).

    Article  CAS  Google Scholar 

  4. Masters, J. J. et al. Angew. Chem. Int. Ed. Engl. 34, 1723–1726 (1995).

    Article  CAS  Google Scholar 

  5. Wender, P. A. et al. J. Am. Chem. Soc. 119, 2755–2756 (1997).

    Article  CAS  Google Scholar 

  6. Mukaiyama, T. et al. Proc. Jpn. Acad. Ser. B 73, 95–100 (1997).

    Article  Google Scholar 

  7. Morihira, K. et al. J. Am. Chem. Soc. 120, 12980–12981 (1998).

    Article  CAS  Google Scholar 

  8. Doi, T. et al. Chem. Asian J. 1, 370–383 (2006).

    Article  CAS  Google Scholar 

  9. Ishihara, Y. & Baran, P. S. Synlett 1733–1745 (2010).

  10. Wender, P. A. et al. Nature Chem. 3, 615–619 10.1038/nchem.1074 (2011).

    Article  CAS  Google Scholar 

  11. Wender, P. A. et al. J. Am. Chem. Soc. 119, 12976–12977 (1997).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Andrew J. Phillips.

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Phillips, A. Function first. Nature Chem 3, 575–576 (2011). https://doi.org/10.1038/nchem.1105

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