Enzymes that selectively oxidize unactivated C–H bonds are capable of constructing complex molecules with high efficiency. A new member of this enzyme family is RedG, a Reiske-type oxygenase that catalyses chemically challenging cyclizations in the biosynthesis of prodiginine natural products.
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References
Davies, H. M. L. & Manning, J. R. Nature 451, 417–424 (2008).
Clardy, J. & Walsh, C. T. Nature 432, 829–837 (2004).
Schofield, C. J. et al. Curr. Opin. Struct. Biol. 6, 857–864 (1997).
Sydor, P. K. et al. Nature Chem. 3, 388–392 (2011 10.1038/nchem.1024).
Cerdeño, A. M., Bibb, M. J. & Challis, G. L. Chem. Biol. 8, 817–829 (2001).
Wasserman, H. H., Shaw, C. K., Sykes, R. J. & Cushley, R. J. Tetrahedron Lett. 15, 2787–2790 (1974).
Haynes, S. W., Sydor, P. K., Stanley, A. E., Song, L. & Challis. G. L. Chem. Commun. 1865–1867 (2008).
Zhu, Y. & Silverman, R. B. Biochemistry 47, 2231–2243 (2008).
Van der Donk, W. A., Krebs, C. & Bollinger, J. M. Curr. Opin. Struct. Biol. 20, 673–683 (2010).
Chakrabarty, S., Austin, R. N., Deng, D., Groves, J. T. & Lipscomb, J. D. J. Am. Chem. Soc. 129, 3514–3515 (2007).
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Bruner, S. C–H activation is a Reiske business. Nature Chem 3, 342–343 (2011). https://doi.org/10.1038/nchem.1038
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DOI: https://doi.org/10.1038/nchem.1038