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The mouse ascending: perspectives for human-disease models

Nature Cell Biology volume 9, pages 993999 (2007) | Download Citation

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The laboratory mouse is widely considered the model organism of choice for studying the diseases of humans, with whom they share 99% of their genes. A distinguished history of mouse genetic experimentation has been further advanced by the development of powerful new tools to manipulate the mouse genome. The recent launch of several international initiatives to analyse the function of all mouse genes through mutagenesis, molecular analysis and phenotyping underscores the utility of the mouse for translating the information stored in the human genome into increasingly accurate models of human disease.

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Author information

Affiliations

  1. Mouse Biology Unit, EMBL Monterotondo Outstation, via Ramarini 32, 00016, Monterotondo, Rome, Italy. rsn@embl-monterotondo.it

    • Nadia Rosenthal
  2. MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK.

    • Steve Brown

Authors

  1. Search for Nadia Rosenthal in:

  2. Search for Steve Brown in:

Competing interests

The authors declare no competing financial interests.

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DOI

https://doi.org/10.1038/ncb437

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