Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

F-actin organizes the nucleus

After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filaments that are required for chromatin decondensation and nuclear expansion at mitotic exit.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Schematic model for the role of nuclear actin filaments in nuclear expansion and chromatin decondensation at mitotic exit.


  1. 1

    Strzelecka, M. & Heald, R. Dev. Cell 31, 259–260 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Magalska, A. et al. Dev. Cell 31, 305–318 (2014).

    CAS  Article  Google Scholar 

  3. 3

    Baarlink, C. et al. Nat. Cell Biol. 19, 1389–1399 (2017).

    CAS  Article  Google Scholar 

  4. 4

    Virtanen, J. A. & Vartiainen, M. K. Curr. Opin. Cell Biol. 46, 33–38 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Grosse, R. & Vartiainen, M. K. Nat. Rev. Mol. Cell Biol. 14, 693–697 (2013).

    CAS  Article  Google Scholar 

  6. 6

    Baarlink, C., Wang, H. & Grosse, R. Science 340, 864–867 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Plessner, M., Melak, M., Chinchilla, P., Baarlink, C. & Grosse, R. J. Biol. Chem. 290, 11209–11216 (2015).

    CAS  Article  Google Scholar 

  8. 8

    Belin, B. J., Lee, T. & Mullins, R. D. eLife 4, e07735 (2015).

    Article  Google Scholar 

  9. 9

    Parisis, N. et al. EMBO J. 36, 3212–3231 (2017).

    CAS  Article  Google Scholar 

  10. 10

    Taniuchi, K. et al. Int. J. Oncol. 44, 1945–1954 (2014).

    CAS  Article  Google Scholar 

  11. 11

    Jha, S. & Dutta, A. Mol. Cell. 34, 521–533 (2009).

    CAS  Article  Google Scholar 

  12. 12

    Ho, C. Y., Jaalouk, D. E., Vartiainen, M. K. & Lammerding, J. Nature 497, 507–511 (2013).

    CAS  Article  Google Scholar 

  13. 13

    Chuang, C. H. et al. Curr. Biol. 16, 825–831 (2006).

    CAS  Article  Google Scholar 

  14. 14

    Mehta, I. S., Amira, M., Harvey, A. J. & Bridger, J. M. Genome Biol. 11, R5 (2010).

    Article  Google Scholar 

  15. 15

    Khanna, N., Hu, Y. & Belmont, A. S. Curr. Biol. 24, 1138–1144 (2014).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Maria K. Vartiainen.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Moore, H., Vartiainen, M. F-actin organizes the nucleus. Nat Cell Biol 19, 1386–1388 (2017).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing