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F-actin organizes the nucleus

After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filaments that are required for chromatin decondensation and nuclear expansion at mitotic exit.

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Figure 1: Schematic model for the role of nuclear actin filaments in nuclear expansion and chromatin decondensation at mitotic exit.


  1. Strzelecka, M. & Heald, R. Dev. Cell 31, 259–260 (2014).

    Article  CAS  Google Scholar 

  2. Magalska, A. et al. Dev. Cell 31, 305–318 (2014).

    Article  CAS  Google Scholar 

  3. Baarlink, C. et al. Nat. Cell Biol. 19, 1389–1399 (2017).

    Article  CAS  Google Scholar 

  4. Virtanen, J. A. & Vartiainen, M. K. Curr. Opin. Cell Biol. 46, 33–38 (2017).

    Article  CAS  Google Scholar 

  5. Grosse, R. & Vartiainen, M. K. Nat. Rev. Mol. Cell Biol. 14, 693–697 (2013).

    Article  CAS  Google Scholar 

  6. Baarlink, C., Wang, H. & Grosse, R. Science 340, 864–867 (2013).

    Article  CAS  Google Scholar 

  7. Plessner, M., Melak, M., Chinchilla, P., Baarlink, C. & Grosse, R. J. Biol. Chem. 290, 11209–11216 (2015).

    Article  CAS  Google Scholar 

  8. Belin, B. J., Lee, T. & Mullins, R. D. eLife 4, e07735 (2015).

    Article  Google Scholar 

  9. Parisis, N. et al. EMBO J. 36, 3212–3231 (2017).

    Article  CAS  Google Scholar 

  10. Taniuchi, K. et al. Int. J. Oncol. 44, 1945–1954 (2014).

    Article  CAS  Google Scholar 

  11. Jha, S. & Dutta, A. Mol. Cell. 34, 521–533 (2009).

    Article  CAS  Google Scholar 

  12. Ho, C. Y., Jaalouk, D. E., Vartiainen, M. K. & Lammerding, J. Nature 497, 507–511 (2013).

    Article  CAS  Google Scholar 

  13. Chuang, C. H. et al. Curr. Biol. 16, 825–831 (2006).

    Article  CAS  Google Scholar 

  14. Mehta, I. S., Amira, M., Harvey, A. J. & Bridger, J. M. Genome Biol. 11, R5 (2010).

    Article  Google Scholar 

  15. Khanna, N., Hu, Y. & Belmont, A. S. Curr. Biol. 24, 1138–1144 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Maria K. Vartiainen.

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Moore, H., Vartiainen, M. F-actin organizes the nucleus. Nat Cell Biol 19, 1386–1388 (2017).

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