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RNA takes over control of DNA break repair

Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.

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Figure 1: RNA:RNA interactions at DNA DSB sites amplify the stimulatory signal for activation of the DDR specifically at these sites.

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Correspondence to Francesca Storici.

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Storici, F., Tichon, A. RNA takes over control of DNA break repair. Nat Cell Biol 19, 1382–1384 (2017). https://doi.org/10.1038/ncb3645

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