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RNA takes over control of DNA break repair

Nature Cell Biology volume 19, pages 13821384 (2017) | Download Citation

Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.

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Author information

Affiliations

  1. Francesca Storici and Ailone E. Tichon are at the School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA

    • Francesca Storici
    •  & Ailone E. Tichon

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Francesca Storici.

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DOI

https://doi.org/10.1038/ncb3645

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