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TYRP1 mRNA goes fishing for miRNAs in melanoma

A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.

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Figure 1: Coding and non-coding functions of TYRP1 mRNA in melanoma.

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Correspondence to Maria S. Soengas.

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Soengas, M., Hernando, E. TYRP1 mRNA goes fishing for miRNAs in melanoma. Nat Cell Biol 19, 1311–1312 (2017). https://doi.org/10.1038/ncb3637

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