Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TYRP1 mRNA goes fishing for miRNAs in melanoma

Nature Cell Biology volume 19, pages 1311–1312 (2017)Cite this article

Subjects

A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Coding and non-coding functions of TYRP1 mRNA in melanoma.

References

  1. Kim, D. et al. Nat. Genet. 48, 1517–1526 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Helwak, A., Kudla, G., Dudnakova, T. & Tollervey, D. Cell 153, 654–655 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Tay, Y., Rinn, J. & Pandolfi, P. P. Nature 505, 344–352 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Gilot, D. et al. Nat. Cell Biol. 19, 1348–1357 (2017).

    Article  CAS  PubMed  Google Scholar 

  5. Shain, A. H. & Bastian, B. C. Nat. Rev. Cancer 16, 345–358 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Garraway, L. A. & Sellers, W. R. Nat. Rev. Cancer 6, 593–602 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Ghanem, G. & Fabrice, J. Mol. Oncol. 5, 150–155 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bolander, A. et al. Cancer Genomics Proteomics 5, 293–300 (2008).

    CAS  PubMed  Google Scholar 

  9. Hoek, K. S. & Goding, C. R. Pigment Cell Melanoma Res. 23, 746–759 (2010).

    Article  CAS  PubMed  Google Scholar 

  10. Journe, F. et al. Br. J. Cancer 105, 1726–1732 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. El Hajj, P. et al. Br. J. Cancer 113, 91–98 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Segura, M. F. et al. Clin. Cancer Res. 16, 1577–1586 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Calin, G. A. et al. N. Engl. J. Med. 353, 1793–1801 (2005).

    Article  CAS  PubMed  Google Scholar 

  14. Loeb, G. B. et al. Mol. Cell 48, 760–770 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Pérez-Guijarro, E. et al. Nat. Commun. 7, 13418 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  16. Alonso-Curbelo, D. et al. Cancer Cell 26, 61–76 (2014).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, 28029, Spain

    Maria S. Soengas

  2. Department of Pathology and Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, New York University School of Medicine, New York, 10016, New York, USA

    Eva Hernando

Authors
  1. Maria S. Soengas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eva Hernando
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maria S. Soengas.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Soengas, M., Hernando, E. TYRP1 mRNA goes fishing for miRNAs in melanoma. Nat Cell Biol 19, 1311–1312 (2017). https://doi.org/10.1038/ncb3637

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3637

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer