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A caspase-independent way to kill cancer cells

Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.

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Figure 1: Caspase-independent cell death, but not apoptosis, activates an anti-cancer immune response.

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Correspondence to Andrew Thorburn.

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Fitzwalter, B., Thorburn, A. A caspase-independent way to kill cancer cells. Nat Cell Biol 19, 1014–1015 (2017). https://doi.org/10.1038/ncb3604

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